Antigenicity of psittacosis vaccines killed by ionizing radiation.
نویسندگان
چکیده
منابع مشابه
Inactivation of Viruses for Vaccines **
Several attempts have been made to use ionizing radiation as a means of inactivating viruses so that they can be employed as killed vaccines. Success has been achieved with a rabies virus, and trials have also been made with poliomyelitis virus.""7 These methods have not been used for practical purposes, partly because of their novelty, because of the expense in the original setting up of the e...
متن کاملImmunity to aerosol challenge in guinea pigs immunized with gamma-irradiated Venezuelan equine encephalitis vaccines.
In a previous report, it was shown that nonviable Venezuelan equine encephalitis (VEE) vaccines prepared by exposure of virus suspensions produced in WI-38 cells to ionizing radiations were highly effective in protecting guinea pigs subjected to intraperitoneal (ip) challenge with VEE virus. To characterize further the efficacy of irradiated vaccines, guinea pigs were immunized with three lots ...
متن کاملPathogens Inactivated by Low-Energy-Electron Irradiation Maintain Antigenic Properties and Induce Protective Immune Responses
Inactivated vaccines are commonly produced by incubating pathogens with chemicals such as formaldehyde or β-propiolactone. This is a time-consuming process, the inactivation efficiency displays high variability and extensive downstream procedures are often required. Moreover, application of chemicals alters the antigenic components of the viruses or bacteria, resulting in reduced antibody speci...
متن کاملImmunization of Mice with Irradiated Pasteurella Tularensis.
Viable attenuated tularemia vaccines have been shown to bt. effective in immunizing mice and other animals against challenge with high].y virulent Pasteurella tularensis. Nonviable preparations, however, induced little or no resistance to challenge with even small numbers of virulent organisms. It seemed reasonable to expect that antigenicity would be retained to a greater extent if the organis...
متن کاملIn Silico Prediction of B-Cell and T-Cell Epitopes of Protective Antigen of Bacillus anthracis in Development of Vaccines Against Anthrax
Protective antigen (PA), a subunit of anthrax toxin from Bacillus anthracis, is known as a dominant component in subunit vaccines in protection against anthrax. In order to avoid the side effects of live attenuated and killed organisms, the use of linear neutralizing epitopes of PA is recommended in order to design recombinant vaccines. The present study is aimed at determining the dominant epi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
دوره 131 3 شماره
صفحات -
تاریخ انتشار 1969